CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	PLN
Protein Name	PPLA_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Cardiac phospholamban (PLB)
Protein Family	Phospholamban family
NCBI Gene ID	5350
UniProt ID	P26678
Enzyme Class	-
Molecular Weight	6109
Protein Length	52
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Endoplasmic reticulum membrane
Function (UniProt annotation)	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Gene Ontology	GO:0002026; GO:0004857; GO:0005246; GO:0005739; GO:0005783; GO:0006816; GO:0007219; GO:0008015; GO:0008016; GO:0010043; GO:0010459; GO:0010881; GO:0016020; GO:0031966; GO:0031982; GO:0032780; GO:0032868; GO:0033017; GO:0033574; GO:0042030; GO:0042802; GO:0043086; GO:0048471; GO:0048738; GO:0051117; GO:0051260; GO:0051480; GO:0051924; GO:0051926; GO:0055119; GO:0060314; GO:0086004; GO:0086023; GO:0086036; GO:0086092; GO:0090281; GO:0090534; GO:1901020; GO:1901877; GO:1901894; GO:1901895; GO:1901897; GO:1902081

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	T17	SAIRRASTIEMPQQA	0.522	0.1731	-	-	-	-	-	-	In vivo
CAMK2D (Q13557)	Homo sapiens	S16	RSAIRRASTIEMPQQ	0.748	0.0888	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S16	RSAIRRASTIEMPQQ	0.748	0.0888	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	T17	SAIRRASTIEMPQQA	0.522	0.1731	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	T17	SAIRRASTIEMPQQA	0.522	0.1731	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	T17	SAIRRASTIEMPQQA	0.522	0.1731	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa05414	Dilated cardiomyopathy

No NCI Nature pathways found