CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	MARK3
Protein Name	MARK3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Protein Family	Protein kinase superfamily
NCBI Gene ID	4140
UniProt ID	P27448
Enzyme Class	2.7.11.1
Molecular Weight	84429
Protein Length	753
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cell membrane
Function (UniProt annotation)	Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).
Gene Ontology	GO:0000165; GO:0000226; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0018105; GO:0030010; GO:0030425; GO:0032092; GO:0035331; GO:0035556; GO:0036289; GO:0050321; GO:0070062

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MARK3* (P27448-3)	Homo sapiens	S598	TPLSQTRSRGSTNLF	0.835	N/A	U	likely	experimental	73 \| 214 \|	15319445	-	In vitro
MARK3* (P27448-3)	Homo sapiens	S601	SQTRSRGSTNLFSKL	0.088	N/A	U	likely	experimental	73 \| 214 \|	15319445	-	In vitro
MARK3* (P27448-3)	Homo sapiens	S606	RGSTNLFSKLTSKLT	0.66	N/A	U	likely	experimental	73 \| 214 \|	15319445	-	In vitro
MARK3* (P27448-3)	Homo sapiens	T602	QTRSRGSTNLFSKLT	0.091	N/A	U	likely	experimental	73 \| 214 \|	15319445	-	In vitro
PIM1* (P11309)	Homo sapiens	S96	KTQLNPTSLQKLFRE	0.741	N/A	U	likely	experimental	214 \| 9 \|	15319445	-	In vitro
PIM1* (P11309)	Homo sapiens	T90	AIKIIDKTQLNPTSL	0.682	N/A	U	likely	experimental	214 \| 9 \|	15319445	-	In vitro
PIM1* (P11309)	Homo sapiens	T95	DKTQLNPTSLQKLFR	0.017	N/A	U	likely	experimental	214 \| 9 \|	15319445	-	In vitro
MARK3 (P27448)	Homo sapiens	S598	TPLSQTRSRGSTNLF	N/A	N/A	-	-	-	-	-	-	-
MARK3 (P27448)	Homo sapiens	S601	SQTRSRGSTNLFSKL	N/A	N/A	-	-	-	-	-	-	-
MARK3 (P27448)	Homo sapiens	S606	RGSTNLFSKLTSKLT	N/A	N/A	-	-	-	-	-	-	-
MARK3 (P27448)	Homo sapiens	T602	QTRSRGSTNLFSKLT	N/A	N/A	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found