CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	PIK3R1
Protein Name	P85A_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Protein Family	PI3K p85 subunit family
NCBI Gene ID	5295
UniProt ID	P27986
Enzyme Class	-
Molecular Weight	83598
Protein Length	724
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Gene Ontology	GO:0001678; GO:0001784; GO:0001953; GO:0005068; GO:0005158; GO:0005159; GO:0005168; GO:0005634; GO:0005737; GO:0005801; GO:0005829; GO:0005886; GO:0005911; GO:0005942; GO:0005943; GO:0006468; GO:0006606; GO:0007173; GO:0007186; GO:0007411; GO:0008134; GO:0008286; GO:0008625; GO:0008630; GO:0014065; GO:0016020; GO:0016032; GO:0016303; GO:0019221; GO:0019903; GO:0030168; GO:0030183; GO:0030335; GO:0031295; GO:0032760; GO:0032869; GO:0033120; GO:0034644; GO:0034976; GO:0035014; GO:0036312; GO:0038095; GO:0038096; GO:0038128; GO:0042307; GO:0043066; GO:0043125; GO:0043548; GO:0043551; GO:0043559; GO:0043560; GO:0045671; GO:0045944; GO:0046326; GO:0046626; GO:0046854; GO:0046934; GO:0046935; GO:0046982; GO:0048009; GO:0048010; GO:0048015; GO:0050821; GO:0050852; GO:0050900; GO:0051492; GO:0051897; GO:0060396; GO:1900103; GO:1903078; GO:1990578; GO:2001275

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
SIK2 (Q9H0K1)	Homo sapiens	S154	STLYRTQSSSNLAEL	0.197	0.2884	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S541	RISEIIDSRRRLEED	0.765	0.3704	-	-	-	-	-	-	in-vitro and in-vivo
PRKD1 (Q15139)	Homo sapiens	S652	TFLVRESSKQGCYAC	0.443	0.2064	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found