| Gene |
NOS1
|
| Protein Name |
NOS1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Nitric oxide synthase, brain (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Peptidyl-cysteine S-nitrosylase NOS1) (bNOS) |
| Protein Family |
NOS family |
| NCBI Gene ID |
4842
|
| UniProt ID |
P29475
|
| Enzyme Class |
1.14.13.39 |
| Molecular Weight |
160970 |
| Protein Length |
1434 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O. |
| Localization |
Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine |
| Function (UniProt annotation) |
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. |
| Gene Ontology |
GO:0001666; GO:0001917; GO:0002028; GO:0003958; GO:0004517; GO:0005516; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0005856; GO:0005886; GO:0005901; GO:0006527; GO:0006809; GO:0006941; GO:0007263; GO:0007520; GO:0009408; GO:0009725; GO:0010181; GO:0010523; GO:0012506; GO:0014069; GO:0016491; GO:0016529; GO:0017080; GO:0018119; GO:0020037; GO:0030018; GO:0030315; GO:0031284; GO:0032496; GO:0032991; GO:0033017; GO:0033555; GO:0034617; GO:0034618; GO:0035066; GO:0042136; GO:0042311; GO:0042383; GO:0042738; GO:0043197; GO:0043267; GO:0044305; GO:0044325; GO:0045121; GO:0045202; GO:0045454; GO:0045776; GO:0045893; GO:0045944; GO:0046870; GO:0048471; GO:0050660; GO:0050661; GO:0050767; GO:0051346; GO:0051612; GO:0051926; GO:0055117; GO:0060314; GO:0071363; GO:0097110; GO:0098735; GO:0098924; GO:0140196; GO:1902307; GO:1902514; GO:1903779 |
