| Gene |
VHL
|
| Protein Name |
VHL_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) |
| Protein Family |
VHL family |
| NCBI Gene ID |
7428
|
| UniProt ID |
P40337
|
| Enzyme Class |
- |
| Molecular Weight |
24153 |
| Protein Length |
213 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.; Isoform 3: Cytoplasm. Nucleus. Note=Equally distributed between the nucleus and the cytoplasm but not membrane-associated. |
| Function (UniProt annotation) |
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. |
| Gene Ontology |
GO:0000122; GO:0000902; GO:0004842; GO:0005634; GO:0005654; GO:0005739; GO:0005783; GO:0005829; GO:0006355; GO:0006508; GO:0008134; GO:0008285; GO:0010629; GO:0016020; GO:0016567; GO:0019899; GO:0030891; GO:0043066; GO:0043687; GO:0045597; GO:0045893; GO:0046426; GO:0050821; GO:0061418; GO:0061428; GO:0061630 |
