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Sequence Viewer
| Parameter | Value |
|---|---|
| Gene | STAT1 |
| Protein Name | STAT1_HUMAN |
| Organism | Homo sapiens (Human) |
| Alternative name(s) | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) |
| Protein Family | Transcription factor STAT family |
| NCBI Gene ID | 6772 |
| UniProt ID | P42224 |
| Enzyme Class | - |
| Molecular Weight | 87335 |
| Protein Length | 750 |
| Protein Domain | InterPro | Pfam |
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase | SwissModel |
| Gene Expression | Gene Expression Atlas |
| Function and Disease | OMIM |
| Protein-protein Interaction Database | STRING | IntAct | MINT |
| Kinase Database | Phospho.ELM | PhosphoSite | NetworKIN |
| Catalytic Activity (UniProt annotation) | - |
| Localization | Cytoplasm |
| Function (UniProt annotation) | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. |
| Gene Ontology | GO:0000122; GO:0000790; GO:0000978; GO:0000979; GO:0000981; GO:0000982; GO:0000983; GO:0001937; GO:0002053; GO:0002230; GO:0003340; GO:0003690; GO:0003700; GO:0005164; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006355; GO:0007221; GO:0007259; GO:0007584; GO:0008015; GO:0009612; GO:0010742; GO:0016032; GO:0016525; GO:0019221; GO:0019899; GO:0030424; GO:0030425; GO:0031730; GO:0032727; GO:0032869; GO:0032991; GO:0033209; GO:0034097; GO:0035035; GO:0035257; GO:0035456; GO:0035458; GO:0038113; GO:0038114; GO:0042393; GO:0042542; GO:0042802; GO:0042803; GO:0042981; GO:0043124; GO:0043434; GO:0044389; GO:0045296; GO:0045648; GO:0045893; GO:0045944; GO:0046725; GO:0048471; GO:0048661; GO:0051591; GO:0051607; GO:0051721; GO:0051770; GO:0060333; GO:0060334; GO:0060337; GO:0061326; GO:0070102; GO:0070106; GO:0070491; GO:0070757; GO:0071346; GO:0071407; GO:0072136; GO:0072162; GO:0072308; GO:1990841 |
Gene Ontology
| Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Camk2a (P11275) | Rattus norvegicus | S727 | TDNLLPMSPEEFDEV | 0.902 | 0.5055 | TP | certain | experimental | 40 | 23 | 73 | 148 | 72 | 9 | | 11972023 | - |
|
| Camk2d (P15791) | Rattus norvegicus | S727 | TDNLLPMSPEEFDEV | 0.902 | 0.5055 | TP | certain | experimental | 40 | 23 | 73 | 148 | 72 | 9 | | 11972023 | - |
|
| Camk2b (P08413) | Rattus norvegicus | S727 | TDNLLPMSPEEFDEV | 0.902 | 0.5055 | TP | certain | experimental | 40 | 23 | 73 | 148 | 72 | 9 | | 11972023 | - |
|
| Camk2g (P11730) | Rattus norvegicus | S727 | TDNLLPMSPEEFDEV | 0.902 | 0.5055 | TP | certain | experimental | 40 | 23 | 73 | 148 | 72 | 9 | | 11972023 | - |
|
| CAMK2G (Q13555) | Homo sapiens | S727 | TDNLLPMSPEEFDEV | 0.902 | 0.5055 | - | - | - | - | - | - |
|
Interaction Network
Reactome Pathways
No KEGG pathways found
No NCI Nature pathways found