CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

Camk2a

Synonyms

N/A

Protein Name

Calcium/calmodulin-dependent protein kinase type II subunit alpha

UniProt ID

P11275

Ensembl Gene ID

N/A

NCBI Gene ID

25400

Molecular Weight

54,115

Protein Length

478

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1CDM)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cell junction, synapse Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Cell projection, dendritic spine Cell projection, dendrite Note=Postsynaptic lipid rafts.

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity).

Gene Ontology

GO:0000082; GO:0002931; GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005954; GO:0006468; GO:0006816; GO:0010666; GO:0014069; GO:0016020; GO:0018105; GO:0030054; GO:0030424; GO:0030425; GO:0032794; GO:0032839; GO:0035235; GO:0035254; GO:0043005; GO:0043025; GO:0043197; GO:0046777; GO:0046872; GO:0046928; GO:0048168; GO:0051928; GO:0060996; GO:0098696; GO:0098970; GO:0098978; GO:0098989; GO:0099004; GO:0099523; GO:0099524; GO:0099573; GO:0099634; GO:1902108; GO:1903076; GO:1990443; GO:2001222

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Nos1 (P29476)	Rattus norvegicus	S847	SYKVRFNSVSSYSDS	-	0.3426	TP	certain	experimental	148 \| 55 \| 72 \| 73 \|	12630910	-	-
Abi1 (Q8CBW3)	Mus musculus	S88	SQLRRMESSINHISQ	-	0.4725	TP	certain	experimental	23 \| 16 \| 72 \| 73 \| 9 \| 55 \| 3 \|	22993434	-	-
STAT1 (P42224)	Homo sapiens	S727	TDNLLPMSPEEFDEV	0.902	0.5055	TP	certain	experimental	40 \| 23 \| 73 \| 148 \| 72 \| 9 \|	11972023	-	-
Drd3 (P30728)	Mus musculus	S229	RILTRQNSQCISIRP	-	0.3087	TP	certain	experimental	40 \| 55 \| 72 \| 9 \| 31 \| 23 \| 73 \| 66 \|	19217379	-	-
Rem2 (Q9WTY2)	Rattus norvegicus	S241	LARSREVSLEEGRHL	-	0.5254	TP	certain	experimental	72 \| 9 \| 16 \|	23575848	-	-
Rem2 (Q9WTY2)	Rattus norvegicus	S308	APPTRRESLTKKAKR	-	0.7369	TP	certain	experimental	72 \| 9 \| 16 \|	23575848	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found