CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	GRIA1
Protein Name	GRIA1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1)
Protein Family	Glutamate-gated ion channel (TC 1.A.10.1) family
NCBI Gene ID	2890
UniProt ID	P42261
Enzyme Class	-
Molecular Weight	101506
Protein Length	906
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Gene Ontology	GO:0000139; GO:0001540; GO:0004971; GO:0005231; GO:0005789; GO:0005886; GO:0006888; GO:0007165; GO:0007268; GO:0007616; GO:0008021; GO:0008066; GO:0009986; GO:0012507; GO:0014069; GO:0030054; GO:0030165; GO:0030425; GO:0030666; GO:0031623; GO:0031901; GO:0032281; GO:0032591; GO:0033116; GO:0043025; GO:0043197; GO:0044308; GO:0044309; GO:0048208; GO:0055037; GO:0055038; GO:0060292; GO:0097060; GO:0098978; GO:0099061; GO:0099583; GO:1904315

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S567	FSPYEWHSEEFEEGR	0.054	0.3249	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S832	LIEFCYKSRSESKRM	0.458	0.1048	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S645	LTVERMVSPIESAED	0.029	0.1323	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S849	FCLIPQQSINEAIRT	0.238	0.1914	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S849	FCLIPQQSINEAIRT	0.238	0.1914	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	S849	FCLIPQQSINEAIRT	0.238	0.1914	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S849	FCLIPQQSINEAIRT	0.238	0.1914	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	S645	LTVERMVSPIESAED	0.029	0.1323	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S645	LTVERMVSPIESAED	0.029	0.1323	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S645	LTVERMVSPIESAED	0.029	0.1323	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04080	Neuroactive ligand-receptor interaction
hsa04720	Long-term potentiation
hsa04724	Glutamatergic synapse
hsa04730	Long-term depression
hsa05014	Amyotrophic lateral sclerosis (ALS)

NCI Nature PID Pathways

Pathway ID	Pathway Name
ephbfwdpathway	EPHB forward signaling