CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	VASP
Protein Name	VASP_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Vasodilator-stimulated phosphoprotein (VASP)
Protein Family	Ena/VASP family
NCBI Gene ID	7408
UniProt ID	P50552
Enzyme Class	-
Molecular Weight	39830
Protein Length	380
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
Function (UniProt annotation)	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.
Gene Ontology	GO:0001843; GO:0003779; GO:0005522; GO:0005829; GO:0005886; GO:0005923; GO:0005925; GO:0007411; GO:0008154; GO:0015629; GO:0017124; GO:0030838; GO:0031258; GO:0031527; GO:0034329; GO:0045296; GO:0051289; GO:0070062

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	T278	LARRRKATQVGEKTP	0.261	0.8872	TP	certain	experimental	72 \| 55 \| 148 \| 73 \| 8 \|	17082196	-	In vitro
PRKD1 (Q15139)	Homo sapiens	S157	EHIERRVSNAGGPPA	0.401	0.9503	TP	certain	experimental	72 \| 147 \| 9 \| 55 \| 73 \| 16 \|	23846685	-	-
PRKD1 (Q15139)	Homo sapiens	S322	TTLPRMKSSSSVTTS	0.364	0.8655	TP	certain	experimental	72 \| 9 \| 55 \| 73 \| 148 \| 16 \|	23846685	-	-
RPS6KA1 (Q15418)	Homo sapiens	T278	LARRRKATQVGEKTP	0.261	0.8872	-	-	-	-	-	-	In vitro and in vivo
PRKD2 (Q9BZL6)	Homo sapiens	S239	GAKLRKVSKQEEASG	0.577	0.8966	-	-	-	-	-	-	in-vivo
PRKD2 (Q9BZL6)	Homo sapiens	S157	EHIERRVSNAGGPPA	0.401	0.9503	-	-	-	-	-	-	in-vivo
PRKD2 (Q9BZL6)	Homo sapiens	S322	TTLPRMKSSSSVTTS	0.364	0.8655	-	-	-	-	-	-	in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04510	Focal adhesion
hsa04666	Fc gamma R-mediated phagocytosis
hsa04670	Leukocyte transendothelial migration

No NCI Nature pathways found