CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| MYLK | Myosin light chain kinase, smooth muscle | Q15746 | MYL12B | CALD1 | Myl12b | MYL2 | CALD1 | MYLK | CALD1 | |
| MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Q9H1R3 | MYL9 | MYL12A | MYL12B | MEF2C | |
| MYLK3 | Myosin light chain kinase 3 | Q32MK0 | Ppp1r2 | PPP1R2B | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| AKT1 | RAC-alpha serine/threonine-protein kinase | P31749 | MAPKAPK2 | SIK2 | PRKD1 | CAMKK2 | |
| BAD | Bcl2-associated agonist of cell death | Q92934 | RPS6KA3 | PRKD1 | RPS6KA2 | RPS6KA1 | PIM3 | PIM1 | CAMK2G | PIM2 | CHEK1 | |
| CTNNB1 | Catenin beta-1 | P35222 | PRKD1 | CAMK2A | PRKAA2 | |
| EGFR | Epidermal growth factor receptor | P00533 | PRKD1 | CAMK2A | PRKAA1 | |
| ELK1 | ETS domain-containing protein Elk-1 | P19419 | RPS6KA5 | |
| ERBB2 | Receptor tyrosine-protein kinase erbB-2 | P04626 | CAMK2A | PRKAA1 | |
| FLNA | Filamin-A | P21333 | RPS6KA1 | CAMK2A | CAMK2B | CAMK2D | CAMK2G | |
| GSK3B | Glycogen synthase kinase-3 beta | P49841 | RPS6KA3 | RPS6KA1 | PRKD3 | STK11 | CAMK2B | |
| ITGB1 | Integrin beta-1 | P05556 | CAMK2A | |
| ITGB4 | Integrin beta-4 | P16144 | RPS6KA1 | |
| JUN | Transcription factor AP-1 | P05412 | PRKD1 | |
| MYL12A | Myosin regulatory light chain 12A | P19105 | MYLK2 | CAMK1 | CAMK4 | DAPK1 | |
| MYL12B | Myosin regulatory light chain 12B | O14950 | MYLK | Dapk1 | MYLK2 | DAPK3 | DAPK1 | |
| MYL9 | Myosin regulatory light polypeptide 9 | P24844 | Camk1 | MYLK2 | DAPK3 | CAMK1 | DAPK1 | DAPK2 | |
| PAK1 | Serine/threonine-protein kinase PAK 1 | Q13153 | BRSK2 | STK11 | |
| PAK2 | Serine/threonine-protein kinase PAK 2 | Q13177 | |
| PPP1R12A | Protein phosphatase 1 regulatory subunit 12A | O14974 | NUAK1 | DAPK3 | |
| PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | P60484 | STK11 | |
| SHC1 | SHC-transforming protein 1 | P29353 | Mapkapk2 | MAPKAPK2 | |
| VASP | Vasodilator-stimulated phosphoprotein | P50552 | PRKAA1 | PRKD1 | RPS6KA1 | PRKD2 | |