| Gene |
BRCA2
|
| Protein Name |
BRCA2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) |
| Protein Family |
N/A |
| NCBI Gene ID |
675
|
| UniProt ID |
P51587
|
| Enzyme Class |
- |
| Molecular Weight |
384202 |
| Protein Length |
3418 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). |
| Gene Ontology |
GO:0000281; GO:0000722; GO:0000724; GO:0000784; GO:0000800; GO:0001556; GO:0001833; GO:0002020; GO:0003697; GO:0005634; GO:0005654; GO:0005813; GO:0005829; GO:0006289; GO:0006302; GO:0006978; GO:0007141; GO:0007283; GO:0007420; GO:0007569; GO:0007584; GO:0008022; GO:0008585; GO:0010165; GO:0010225; GO:0010332; GO:0010484; GO:0010485; GO:0010778; GO:0030097; GO:0030141; GO:0030879; GO:0031619; GO:0032355; GO:0032465; GO:0032991; GO:0033593; GO:0033600; GO:0035264; GO:0042771; GO:0042802; GO:0043015; GO:0043150; GO:0043966; GO:0043967; GO:0045893; GO:0045931; GO:0048478; GO:0051298; GO:0051598; GO:0070200; GO:1990426 |
