CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	RRAD
Protein Name	RAD_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	GTP-binding protein RAD (RAD1) (Ras associated with diabetes)
Protein Family	Small GTPase superfamily
NCBI Gene ID	6236
UniProt ID	P55042
Enzyme Class	-
Molecular Weight	33245
Protein Length	308
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Gene Ontology	GO:0003924; GO:0005516; GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:1901842

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S273	AGTRRRESLGKKAKR	0.915	0.5017	-	-	-	-	-	-	In vitro
CAMK2G (Q13555)	Homo sapiens	S273	AGTRRRESLGKKAKR	0.915	0.5017	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found