CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	H3F3A; H3F3B
Protein Name	H33_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histone H3.3
Protein Family	Histone H3 family
NCBI Gene ID	30203021
UniProt ID	P84243
Enzyme Class	-
Molecular Weight	15328
Protein Length	136
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus. Chromosome.
Function (UniProt annotation)	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Gene Ontology	GO:0000183; GO:0000228; GO:0000784; GO:0000786; GO:0000788; GO:0000979; GO:0000980; GO:0001649; GO:0001740; GO:0005576; GO:0005634; GO:0005654; GO:0006334; GO:0006336; GO:0006997; GO:0007286; GO:0007338; GO:0007420; GO:0007566; GO:0007596; GO:0008283; GO:0008584; GO:0009725; GO:0030307; GO:0031492; GO:0031508; GO:0031509; GO:0032200; GO:0032991; GO:0035264; GO:0042692; GO:0044267; GO:0045652; GO:0045814; GO:0046982; GO:0048477; GO:0060964; GO:0070062; GO:0090230; GO:1902340

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA5 (O75582)	Homo sapiens	S11	TKQTARKSTGGKAPR	0.568	0.7718	-	-	-	-	-	-	-
RPS6KA5 (O75582)	Homo sapiens	S29	ATKAARKSAPSTGGV	0.558	0.6948	-	-	-	-	-	-	-
RPS6KA3 (P51812)	Homo sapiens	S11	TKQTARKSTGGKAPR	0.568	0.7718	-	-	-	-	-	-	-
CHEK1 (O14757)	Homo sapiens	S32	AARKSAPSTGGVKKP	0	0.7036	-	-	-	-	-	-	in-vitro and in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus

No NCI Nature pathways found