| Gene |
E2F1
|
| Protein Name |
E2F1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) |
| Protein Family |
E2F/DP family |
| NCBI Gene ID |
1869
|
| UniProt ID |
Q01094
|
| Enzyme Class |
- |
| Molecular Weight |
46920 |
| Protein Length |
437 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). |
| Gene Ontology |
GO:0000077; GO:0000083; GO:0000122; GO:0000790; GO:0000981; GO:0000987; GO:0001077; GO:0001078; GO:0001227; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005739; GO:0005813; GO:0006351; GO:0006355; GO:0006977; GO:0007283; GO:0008134; GO:0008630; GO:0010628; GO:0019901; GO:0030900; GO:0032991; GO:0035189; GO:0043065; GO:0043276; GO:0043392; GO:0043565; GO:0045599; GO:0045892; GO:0045893; GO:0045944; GO:0046983; GO:0048146; GO:0048255; GO:0051726; GO:0060252; GO:0070317; GO:0070345; GO:0071398; GO:0071456; GO:0071466; GO:0071930; GO:0072332; GO:0090575; GO:1900740; GO:1990086; GO:1990090; GO:2000045 |
