CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	GRIN2B
Protein Name	NMDE2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Protein Family	Glutamate-gated ion channel (TC 1.A.10.1) family
NCBI Gene ID	2904
UniProt ID	Q13224
Enzyme Class	-
Molecular Weight	166367
Protein Length	1484
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
Gene Ontology	GO:0000165; GO:0004972; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007215; GO:0007268; GO:0007275; GO:0007420; GO:0007611; GO:0008270; GO:0009986; GO:0014069; GO:0016594; GO:0016595; GO:0017146; GO:0022849; GO:0030054; GO:0043005; GO:0045211; GO:0045471; GO:0048013; GO:0048167; GO:0051290; GO:0060079; GO:0060291; GO:0097060; GO:0097553; GO:0098839; GO:0098976; GO:1901216; GO:1902951; GO:2001056

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S1303	NKLRRQHSYDTFVDL	0.872	0.5854	-	-	-	-	-	-	In vitro
DAPK1 (P53355)	Homo sapiens	S1303	NKLRRQHSYDTFVDL	0.872	0.5854	-	-	-	-	-	-	in-vitro
CAMK2B (Q13554)	Homo sapiens	S1303	NKLRRQHSYDTFVDL	0.872	0.5854	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S1303	NKLRRQHSYDTFVDL	0.872	0.5854	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S1303	NKLRRQHSYDTFVDL	0.872	0.5854	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S383	VGKWKDKSLQMKYYV	0.724	0.1048	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	S383	VGKWKDKSLQMKYYV	0.724	0.1048	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S383	VGKWKDKSLQMKYYV	0.724	0.1048	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S383	VGKWKDKSLQMKYYV	0.724	0.1048	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04080	Neuroactive ligand-receptor interaction
hsa04720	Long-term potentiation
hsa04724	Glutamatergic synapse
hsa05010	Alzheimer's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05016	Huntington's disease
hsa05322	Systemic lupus erythematosus

NCI Nature PID Pathways

Pathway ID	Pathway Name
reelinpathway	Reelin signaling pathway