CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	SKP2
Protein Name	SKP2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Protein Family	N/A
NCBI Gene ID	6502
UniProt ID	Q13309
Enzyme Class	-
Molecular Weight	47761
Protein Length	424
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Gene Ontology	GO:0000082; GO:0000086; GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0008283; GO:0016032; GO:0016579; GO:0019005; GO:0031146; GO:0033148; GO:0042802; GO:0042981; GO:0043161; GO:0043687; GO:0045087; GO:0048661; GO:0051607; GO:0051726; GO:0061630; GO:0070936; GO:0071460; GO:1902916

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Pim1* (P26794)	Rattus norvegicus	S72	PPRKRLKSKGSDKDF	0.303	0.4864	TP	certain	experimental	40 \| 148 \| 9 \| 72 \| 73 \|	20663873	-	-
Pim1* (P26794)	Rattus norvegicus	S64	SNLGHPESPPRKRLK	0.183	0.5951	TP	certain	experimental	40 \| 148 \| 9 \| 72 \| 73 \|	20663873	-	-
Pim1 (P26794)	Rattus norvegicus	T417	WGIKCRLTLQKPSCL	0.106	0.0253	TP	certain	experimental	40 \| 148 \| 9 \| 72 \| 73 \|	20663873	-	-
PIM1 (P11309)	Homo sapiens	S64	SNLGHPESPPRKRLK	0.183	0.5951	-	-	-	-	-	-	In vivo
PIM1 (P11309)	Homo sapiens	S72	PPRKRLKSKGSDKDF	0.303	0.4864	-	-	-	-	-	-	In vivo
PIM1 (P11309)	Homo sapiens	T417	WGIKCRLTLQKPSCL	0.106	0.0253	-	-	-	-	-	-	In vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04110	Cell cycle
hsa04120	Ubiquitin mediated proteolysis
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
foxm1pathway	FOXM1 transcription factor network
foxopathway	FoxO family signaling