| Gene |
PLD1
|
| Protein Name |
PLD1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) |
| Protein Family |
Phospholipase D family |
| NCBI Gene ID |
5337
|
| UniProt ID |
Q13393
|
| Enzyme Class |
3.1.4.4 |
| Molecular Weight |
124184 |
| Protein Length |
1074 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
A phosphatidylcholine + H(2)O = choline + a phosphatidate. |
| Localization |
Cytoplasm, perinuclear region |
| Function (UniProt annotation) |
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). |
| Gene Ontology |
GO:0000139; GO:0004630; GO:0005765; GO:0005768; GO:0005789; GO:0005794; GO:0005886; GO:0006654; GO:0006935; GO:0007264; GO:0007265; GO:0016020; GO:0016042; GO:0016324; GO:0030139; GO:0031902; GO:0032534; GO:0035091; GO:0035579; GO:0043312; GO:0048017; GO:0048471; GO:0048870; GO:0070290; GO:0070821; GO:0098693; GO:0098981 |
