CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	BECN1
Protein Name	BECN1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Protein Family	Beclin family
NCBI Gene ID	8678
UniProt ID	Q14457
Enzyme Class	-
Molecular Weight	51896
Protein Length	450
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Gene Ontology	GO:0000045; GO:0000407; GO:0000422; GO:0000423; GO:0001666; GO:0005634; GO:0005768; GO:0005776; GO:0005783; GO:0005789; GO:0005802; GO:0005829; GO:0006914; GO:0006915; GO:0006968; GO:0006995; GO:0007040; GO:0007080; GO:0007568; GO:0008285; GO:0010008; GO:0010040; GO:0010288; GO:0010613; GO:0014068; GO:0016032; GO:0016236; GO:0016579; GO:0019898; GO:0019901; GO:0030425; GO:0031625; GO:0031966; GO:0032258; GO:0032465; GO:0032801; GO:0033197; GO:0034198; GO:0034271; GO:0034272; GO:0035032; GO:0042149; GO:0042803; GO:0043066; GO:0043548; GO:0043652; GO:0045022; GO:0045324; GO:0045335; GO:0048666; GO:0050435; GO:0050790; GO:0051020; GO:0051301; GO:0051607; GO:0060548; GO:0070301; GO:0071275; GO:0071280; GO:0071364; GO:0098780; GO:1902425; GO:1902902; GO:1905672; GO:2000378; GO:2000786

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
DAPK1 (P53355)	Homo sapiens	S90	IPPARMMSTESANSF	0.467	0.4652	TP	likely	-	148 \| 55 \| 73 \|	26994142	-	-
DAPK1 (P53355)	Homo sapiens	T119	LSRRLKVTGDLFDIM	0.202	0.4087	TP	certain	-	73 \| 3 \| 9 \| 214 \| 55 \| 8 \| 74 \| 30 \| 40 \| 107 \|	19180116	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S90	IPPARMMSTESANSF	0.467	0.4652	-	-	-	-	-	-	in-vitro and in-vivo
MAPKAPK2 (P49137)	Homo sapiens	S90	IPPARMMSTESANSF	0.467	0.4652	-	-	-	-	-	-	in-vitro and in-vivo
MAPKAPK3 (Q16644)	Homo sapiens	S90	IPPARMMSTESANSF	0.467	0.4652	-	-	-	-	-	-	in-vitro
DAPK3 (O43293)	Homo sapiens	S90	IPPARMMSTESANSF	0.467	0.4652	-	-	-	-	-	-	in-vitro and in-vivo
PRKAA1 (Q13131)	Homo sapiens	T388	EEVEKGETRFCLPYR	0.131	0.1611	-	-	-	-	-	-	in-vitro and in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04140	Regulation of autophagy

No NCI Nature pathways found