| Gene |
PEA15
|
| Protein Name |
PEA15_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) |
| Protein Family |
N/A |
| NCBI Gene ID |
8682
|
| UniProt ID |
Q15121
|
| Enzyme Class |
- |
| Molecular Weight |
15040 |
| Protein Length |
130 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Note=Associated with microtubules. |
| Function (UniProt annotation) |
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. |
| Gene Ontology |
GO:0000077; GO:0000165; GO:0000187; GO:0005634; GO:0005829; GO:0005875; GO:0006915; GO:0008643; GO:0043278; GO:0046325; GO:1902042; GO:1902043 |
