CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	NFKBIB
Protein Name	IKBB_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Protein Family	NF-kappa-B inhibitor family
NCBI Gene ID	4793
UniProt ID	Q15653
Enzyme Class	-
Molecular Weight	37771
Protein Length	356
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Gene Ontology	GO:0003713; GO:0005634; GO:0005829; GO:0006351; GO:0007165; GO:0071222

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA1 (Q15418)	Homo sapiens	S19	DADEWCDSGLGSLGP	0.929	0.3599	-	-	-	-	16822942	Non high throughput (16822942)	-
RPS6KA1 (Q15418)	Homo sapiens	S23	WCDSGLGSLGPDAAA	0.928	0.4186	-	-	-	-	16822942	Non high throughput (16822942)	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04062	Chemokine signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05131	Shigellosis
hsa05140	Leishmaniasis
hsa05145	Toxoplasmosis
hsa05162	Measles
hsa05164	Influenza A

NCI Nature PID Pathways

Pathway ID	Pathway Name
bcr_5pathway	BCR signaling pathway