KEGG pathway - Neurotrophin signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Q9UQM7	KCND2 \| Nos1 \| PLCB3 \| Nlgn1 \| Ryr2 \| Ryr2 \| Trpv1 \| Syn1 \| EGFR \| NEFL \| TH \| TH \| CACNA1S \| Gja1 \| VIM \| ALOX5 \| MPZ \| MAPT \| Camk2a \| Mylk \| SRF \| CALD1 \| ETS1 \| ETS2 \| Lipe \| Creb1 \| CACNA1C \| CACNA1C \| CD44 \| SYN1 \| Ptpra \| Spr \| Drd3 \| Gria1 \| Gria4 \| FLNA \| Gabrg2 \| Gria1 \| Gjc1 \| MAPT \| NOS1 \| Nos1 \| Vim \| Dlg4 \| Oprm1 \| Ptk2 \| SPR \| HRH1 \| OPRM1 \| SNCA \| GRIA1 \| CDKN1B \| Rph3a \| PLA2G4A \| VIM \| Gabrb1 \| CLCN3 \| RRAD \| PLN \| Pln \| Cdk5r1 \| Il6st \| Mecp2 \| HSF1 \| Grin2b \| Cacna1c \| Cacna1b \| GFPT1 \| GRIN2B \| ESPL1 \| SMAD2 \| Dlg1 \| Kcnd2 \| Tph2 \| RYR2 \| PPP1R14A \| RCHY1 \| CARD11 \| Rims1 \| Pdc \| Lrp4 \| Gabbr1 \| PEA15 \| FBXO43 \| Brsk1 \| SLN \| ITGB1BP1 \| ERBB2 \| ITGB1 \| Chrm4 \| Myog \| TNNT2 \| ITPKA \| PLN \| CHAT \| GLO1 \| Myh9 \| Sln \| Sln \| CAMK2A \| \| NCOR2 \| Itpr2 \| HDAC5 \| Mcu \| Mybpc3 \| TH \| Kif3a \| Slc6a3 \| TCAP \| STMN1 \| Cpeb3 \| KIF3A \| Ppp3ca \| DAGLA \| Abi1 \| NOX5 \| SLC6A4 \| Syngap1 \| KCNQ2 \| Neto2 \| CTNNB1 \| BECN1 \| DLGAP1 \| Wee2 \| ID1 \| Fosb \| NR1H2 \| Psmc5 \| KCNJ11 \| Grm1 \| SLC1A3 \| Trpc6 \| Dpysl2 \| TNNT2 \| DLG1 \| GABRG2 \| PDC \| CLCN3 \| PTPRA \| BCL10 \| KRT18 \| MAPT \| MAPT \| CREB1 \| ATP2A2 \| PTPRA \| PDC \| DRD3 \| DLG1 \| IRF3 \| ABI1 \| HOMER3 \| RYR2 \| TRPV1 \| SYN1 \| NEFL \| CACNA1S \| \| MPZ \| CAMK2A \| CALD1 \| CALD1 \| \| CACNA1C \| CACNA1C \| GRIA4 \| \| GJC1 \| MAPT \| NOS1 \| DLG4 \| PTK2 \| RPH3A \| GABRB1 \| CDK5R1 \| IL6ST \| MECP2 \| CACNA1B \| KCND2 \| TPH2 \| RIMS1 \| LRP4 \| \| PEA15 \| \| GFAP \| \| PDC \| SYNGAP1 \| MCU \| MYBPC3 \| KIF3A \| SLC6A3 \| CPEB3 \| PPP3CA \| FOSB \| \| ATP2A2 \| CEBPB \| CFL2 \| ADCY3 \| QDPR \| GFAP \| ACACA \| RYR1 \| PPP1R9B \| MYLK \| ITGB1BP1 \| CHAT \| BRSK1 \| CHRM4 \| MYF4 \| SLN \| nlgn1 \| GRM1 \| TRPC6 \| \| VPS72 \| \|
CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta	Q13554	RYR1 \| CAMK2B \| STMN1 \| Gsk3a \| Gsk3b \| PRKAA1 \| DLGAP1 \| OCLN \| GRIN2B \| GSK3A \| GSK3B \| TH \| CREB1 \| ATP2A2 \| CEBPB \| FLNA \| PEA15 \| CFL2 \| DLG1 \| ADCY3 \| KRT18 \| QDPR \| GFAP \| GRIA1 \| HSF1 \| PLCB3 \| KCND2 \| SYN1 \| ACACA \| RYR1 \| VIM \| RYR2 \| PPP3CA \| OPRM1 \| PPP1R9B \| PLN \| CAMK2B \| VPS72 \| \| CAMK2A \|
CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	Ryr2 \| ANKRD28 \| HDAC4 \| SCN5A \| CACNB2 \| Itpr2 \| Pln \| CEACAM1 \| TTN \| OCLN \| KCNJ11 \| VIM \| CREB1 \| TPD52 \| HSF1 \| ITPR2 \| HIST3H3 \| SSH1 \| RYR2 \| HDAC5 \| RYR2 \| PLN \| TH \| ATP2A2 \| CEBPB \| FLNA \| PEA15 \| CFL2 \| DLG1 \| ADCY3 \| KRT18 \| QDPR \| GFAP \| GRIA1 \| PLCB3 \| KCND2 \| SYN1 \| ACACA \| RYR1 \| PPP3CA \| GRIN2B \| OPRM1 \| PPP1R9B \| CAMK2D \| VPS72 \| \| CAMK2A \|
CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Q13555	Bad \| STAT3 \| RELA \| RARA \| CAMK2G \| DAB2 \| OCLN \| RRAD \| BAD \| \| \| TH \| \| RYR1 \| STAT1 \| GRIA1 \| PEA15 \| CREB1 \| ATP2A2 \| CEBPB \| FLNA \| CFL2 \| DLG1 \| ADCY3 \| KRT18 \| QDPR \| GFAP \| HSF1 \| PLCB3 \| KCND2 \| SYN1 \| ACACA \| VIM \| RYR2 \| PPP3CA \| GRIN2B \| OPRM1 \| PPP1R9B \| VPS72 \| PLN \| \| CAMK2A \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV	Q16566	Creb1 \| Myh9 \| HDAC5 \| Crebbp \| CAMK4 \| HNRNPL \| STMN1 \| SIK2 \| PHB2 \| CABIN1 \| SRF \| CREB1 \| CAMK2A \| Crebbp \| LIMK1 \| Hspb1 \| Camk4 \| MYL12A \| HDAC4 \| RELA \| EP300 \| CREBBP \| Snf1lk2 \| NUMB \| HSPB1 \| NOS1 \| ACACA \| SYN1 \| SNF1LK2 \| CAMK1 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1	Q15418	EEF2K \| MITF \| FOS \| ESR1 \| Nr4a1 \| ITGB4 \| CREB1 \| SLC9A1 \| FLNA \| EIF4B \| NFKBIA \| L1CAM \| IRS1 \| TSC2 \| Tsc2 \| GSK3B \| ETV1 \| DAPK1 \| RPS6 \| YBX1 \| CCT2 \| MDM2 \| MXD1 \| Mitf \| RPS6KA1 \| NFKBIB \| PPP1R3A \| Bad \| Kcnd3 \| Rps6ka1 \| Dlc1 \| Eif4b \| RPTOR \| DEPTOR \| ESR2 \| BAD \| CIC \| RANBP3 \| Krt17 \| METTL1 \| NDRG2 \| CARHSP1 \| Nos1 \| Cebpb \| CEBPB \| CDKN1B \| VASP \| GMFB \| Cebpb \| UBR5 \| Mapk7 \| MAPK7 \| WWC1 \| Gab2 \| CDC25C \| CHEK1 \| PDCD4 \| SOS1 \| LCP1 \| APAF1 \| Senp2 \| OSTF1 \| CDC25A \| EPHA2 \| CDC25B \| SLC9A3R1 \| CDC34 \| SENP2 \|
RPS6KA2	Ribosomal protein S6 kinase alpha-2	Q15349	FOS \| CREB1 \| ATF4 \| DAPK1 \| MEF2C \| Atf4 \| NFATC4 \| BAD \| RRN3 \| CDKN1B \| RPS6KA2 \|
RPS6KA3	Ribosomal protein S6 kinase alpha-3	P51812	KCNK3 \| ESR1 \| EIF2S1 \| Nr4a1 \| Htr2a \| Creb1 \| ATF4 \| EIF2AK2 \| Cebpb \| NFKBIA \| HIST1H2BB \| STAT3 \| Gata4 \| CDKN1B \| GSK3A \| GSK3B \| DAPK1 \| Mybpc3 \| RPS6 \| YBX1 \| PPP1R3A \| NFATC4 \| RRN3 \| HMGN1 \| TH \| TH \| TH \| CREB1 \| PFKFB2 \| Mybpc3 \| Rps6 \| HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J \| H3F3A; H3F3B \| PPP1R3A \| BAD \| CIC \| RANBP3 \| MAP3K5 \| WWC1 \| TH \| TINF2 \| LCP1 \| TBX21 \| FGFR1 \| STMN1 \| EPHA2 \| SLC9A3 \| CASP8 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5	O75582	RPS6KA5 \| HMGN1 \| TH \| HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM \| SRF \| Nr4a1 \| Creb1 \| CREB1 \| ATF1 \| ELK1 \| PLA2G4A \| HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J \| Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i \| H3F3A; H3F3B \| RELA \| Rela \| Eif4ebp1 \| Bad \| WNK1 \| Hist1h2ad \| Hist1h2ab \| RARA \| ATXN1 \| Trim28 \|
RPS6KA6	Ribosomal protein S6 kinase alpha-6	Q9UK32
MAPKAPK2	MAP kinase-activated protein kinase 2	P49137	TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| SRF \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| AGO2 \| PARN \| CRYAB \| Creb1 \| CREB1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| HNRNPA0 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4	O75676	CREB1 \| RELA \| RPS6KA4 \| Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
AKT1	RAC-alpha serine/threonine-protein kinase	P31749	MAPKAPK2 \| SIK2 \| PRKD1 \| CAMKK2 \|
ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	RPS6KA3 \| RPS6KA2 \|
BAD	Bcl2-associated agonist of cell death	Q92934	RPS6KA3 \| PRKD1 \| RPS6KA2 \| RPS6KA1 \| PIM3 \| PIM1 \| CAMK2G \| PIM2 \| CHEK1 \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Q9UQM7	CAMK2A \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Q9UQM7	CAMK2A \|
CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Q13555	CAMK2G \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV	Q16566	CAMKK1 \| CAMK4 \| CAMK1 \|
FOXO3	Forkhead box protein O3	O43524	PIM1 \| PRKAA2 \| PRKAA1 \| MAPKAPK5 \|
GSK3B	Glycogen synthase kinase-3 beta	P49841	RPS6KA3 \| RPS6KA1 \| PRKD3 \| STK11 \| CAMK2B \|
IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta	O14920	PRKAA2 \|
IRS1	Insulin receptor substrate 1	P35568	Sik2 \| SIK1 \| RPS6KA1 \| PIM2 \| PIM3 \| PIM1 \| SIK2 \|
JUN	Transcription factor AP-1	P05412	PRKD1 \|
MAP3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	PIM1 \| Melk \| RPS6KA3 \| PRKD1 \| MELK \|
MAPKAPK2	MAP kinase-activated protein kinase 2	P49137	MAPKAPK2 \|
NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEK1 \|
NFKBIA	NF-kappa-B inhibitor alpha	P25963	RPS6KA3 \| RPS6KA1 \|
NFKBIB	NF-kappa-B inhibitor beta	Q15653	RPS6KA1 \|
RELA	Transcription factor p65	Q04206	PIM1 \| CAMK2G \| RPS6KA4 \| RPS6KA5 \| CAMK4 \| CHEK1 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1	Q15418	RPS6KA1 \| MAPKAPK2 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4	O75676	RPS6KA4 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5	O75582	RPS6KA5 \|
SHC1	SHC-transforming protein 1	P29353	Mapkapk2 \| MAPKAPK2 \|
TP53	Cellular tumor antigen p53	P04637	DAPK1 \| MAPKAPK2 \| STK11 \| NUAK1 \| MAPKAPK5 \| STK17A \| CHEK1 \| DAPK3 \| CHEK2 \| PRKAA1 \| SIK1 \| MELK \| PRKAA2 \|
TP73	Tumor protein p73	O15350	CHEK1 \| PRKAA1 \|
YWHAZ	14-3-3 protein zeta/delta	P63104	MAPKAPK2 \|