CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	PHKG1
Protein Name	PHKG1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26)
Protein Family	Protein kinase superfamily
NCBI Gene ID	5260
UniProt ID	Q16816
Enzyme Class	2.7.11.19; 2.7.11.1; 2.7.11.26
Molecular Weight	45024
Protein Length	387
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	2 ATP + phosphorylase b = 2 ADP + phosphorylase a.; ATP + [tau protein] = ADP + [tau protein] phosphate.; ATP + a protein = ADP + a phosphoprotein.
Localization	N/A
Function (UniProt annotation)	Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).
Gene Ontology	GO:0004683; GO:0004689; GO:0005516; GO:0005524; GO:0005829; GO:0005964; GO:0005975; GO:0005978; GO:0019899; GO:0050321

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PHKG1 (Q16816)	Homo sapiens	S31	EILGRGVSSVVRRCI	0.815	0.346	-	-	-	-	-	-	-
PHKG2 (P15735)	Homo sapiens	S31	EILGRGVSSVVRRCI	0.815	0.346	-	-	-	-	-	-	-
PHKG1 (Q16816)	Homo sapiens	S82	VDILRKVSGHPNIIQ	0.309	0.2034	-	-	-	-	-	-	-
PHKG2 (P15735)	Homo sapiens	S82	VDILRKVSGHPNIIQ	0.309	0.2034	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found