CaMKipedia | Result

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Sequence Viewer

Gene

PHKG1

Synonyms

PHKG

Protein Name

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

UniProt ID

Q16816

Ensembl Gene ID

9606.ENSP00000297373

NCBI Gene ID

5260

Molecular Weight

45,024

Protein Length

387

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.19; 2.7.11.1; 2.7.11.26 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

2 ATP + phosphorylase b = 2 ADP + phosphorylase a.; ATP + [tau protein] = ADP + [tau protein] phosphate.; ATP + a protein = ADP + a phosphoprotein.

Localization

N/A

Function

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).

Gene Ontology

GO:0004683; GO:0004689; GO:0005516; GO:0005524; GO:0005829; GO:0005964; GO:0005975; GO:0005978; GO:0019899; GO:0050321

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
GAP43 (P06836)	Bos taurus	S41	AATKIQASFRGHITR	-	0.712	-	-	-	-	-	-	In vitro
NRGN (P35722)	Bos taurus	S36	AAAKIQASFRGHMAR	-	0.5577	-	-	-	-	-	-	In vitro
GAP43 (P17677-2)	Homo sapiens	S77	DEAPVADGVEKKGEG	-	-	-	-	-	-	-	-	-
MAPT (P10636-2)	Homo sapiens	S204	NVKSKIGSTENLKHQ	-	-	-	-	-	-	-	-	-
MAPT (P10636-6)	Homo sapiens	S179	RTPPKSPSSAKSRLQ	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S237	RTPPKSPSSAKSRLQ	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S262	NVKSKIGSTENLKHQ	-	-	-	-	-	-	-	-	-
NRGN (A0A024R3M7)	Homo sapiens	S36	AAAKIQASFRGHMAR	-	0.5419	-	-	-	-	-	-	-
PYGM (P11217)	Homo sapiens	S15	QEKRKQISVRGLAGV	0.856	0.3599	-	-	-	-	-	-	-
PYGB (P11216)	Homo sapiens	S15	SEKRKQISVRGLAGL	0.873	0.2884	-	-	-	-	-	-	-
PHKG1 (Q16816)	Homo sapiens	S31	EILGRGVSSVVRRCI	0.815	0.346	-	-	-	-	-	-	-
PHKG1 (Q16816)	Homo sapiens	S82	VDILRKVSGHPNIIQ	0.309	0.2034	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S985	SNVSPAISIHEIGAV	0.127	0.4441	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S1007	TGIMQLKSEIKQVEF	0.746	0.3667	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S972	KEFGVERSVRPTDSN	0.264	0.562	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S1018	QVEFRRLSISAESQS	0.358	0.4619	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S352	DFKDRVQSKIGSLDN	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S305	KHVPGGGSVQIVYKP	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S285	INKKLDLSNVQSKCG	-	-	-	-	-	-	-	-	-
TNNT3 (P45378)	Homo sapiens	S167	SMGANYSSYLAKADQ	0.209	0.5493	-	-	-	-	-	-	-
TNNT3 (P45378)	Homo sapiens	S2	______MSDEEVEQV	0.5	0.9151	-	-	-	-	-	-	-
TNNT3 (P45378)	Homo sapiens	S160	KKKKALSSMGANYSS	0.274	0.4801	-	-	-	-	-	-	-
TNNI3 (P19429)	Homo sapiens	S77	GEKGRALSTRCQPLE	0.409	0.5533	-	-	-	-	-	-	-
TNNI2 (A0A087WXS0)	Homo sapiens	T12	QKRNRAITARRQHLK	-	0.562	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa04910	Insulin signaling pathway

No NCI Nature pathways found