CaMKipedia | Result

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Sequence Viewer

Gene

PHKG2

Synonyms

N/A

Protein Name

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

UniProt ID

P15735

Ensembl Gene ID

9606.ENSP00000455607

NCBI Gene ID

5261

Molecular Weight

46,442

Protein Length

406

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2y7j)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.19 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

2 ATP + phosphorylase b = 2 ADP + phosphorylase a.

Localization

N/A

Function

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).

Gene Ontology

GO:0004674; GO:0004683; GO:0004689; GO:0005516; GO:0005524; GO:0005829; GO:0005964; GO:0005977; GO:0005978; GO:0006091; GO:0006468; GO:0019899; GO:0045819; GO:0050321

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PYGM (P11217)	Homo sapiens	S15	QEKRKQISVRGLAGV	0.856	0.3599	-	-	-	-	-	-	-
PYGB (P11216)	Homo sapiens	S15	SEKRKQISVRGLAGL	0.873	0.2884	-	-	-	-	-	-	-
PHKG1 (Q16816)	Homo sapiens	S31	EILGRGVSSVVRRCI	0.815	0.346	-	-	-	-	-	-	-
PHKG1 (Q16816)	Homo sapiens	S82	VDILRKVSGHPNIIQ	0.309	0.2034	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S985	SNVSPAISIHEIGAV	0.127	0.4441	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S1007	TGIMQLKSEIKQVEF	0.746	0.3667	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S972	KEFGVERSVRPTDSN	0.264	0.562	-	-	-	-	-	-	-
PHKA1 (P46020)	Homo sapiens	S1018	QVEFRRLSISAESQS	0.358	0.4619	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S237	RTPPKSPSSAKSRLQ	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S352	DFKDRVQSKIGSLDN	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S305	KHVPGGGSVQIVYKP	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S285	INKKLDLSNVQSKCG	-	-	-	-	-	-	-	-	-
MAPT (P10636-8)	Homo sapiens	S262	NVKSKIGSTENLKHQ	-	-	-	-	-	-	-	-	-
TNNT3 (P45378)	Homo sapiens	S167	SMGANYSSYLAKADQ	0.209	0.5493	-	-	-	-	-	-	-
TNNT3 (P45378)	Homo sapiens	S2	______MSDEEVEQV	0.5	0.9151	-	-	-	-	-	-	-
TNNT3 (P45378)	Homo sapiens	S160	KKKKALSSMGANYSS	0.274	0.4801	-	-	-	-	-	-	-
TNNI3 (P19429)	Homo sapiens	S77	GEKGRALSTRCQPLE	0.409	0.5533	-	-	-	-	-	-	-
TNNI2 (A0A087WXS0)	Homo sapiens	T12	QKRNRAITARRQHLK	-	0.562	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa04910	Insulin signaling pathway

No NCI Nature pathways found