CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CRTC3
Protein Name	CRTC3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)
Protein Family	TORC family
NCBI Gene ID	64784
UniProt ID	Q6UUV7
Enzyme Class	-
Molecular Weight	66959
Protein Length	619
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Gene Ontology	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008140; GO:0016032; GO:0032793; GO:0042116; GO:0043951; GO:0045944; GO:0050995; GO:0051289; GO:0097009

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Sik1 (Q60670)	Mus musculus	S162	SALNRTNSDSALHTS	0.89	0.6322	TP	certain	experimental	72 \|	16817901	-	-
SIK1 (P57059)	Homo sapiens	S162	SALNRTNSDSALHTS	0.89	0.6322	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S329	SGLQSSRSNPSIQAT	0.525	0.7505	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S370	SLRLFSLSNPSLSTT	0.898	0.5139	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S62	LTQYHGGSLPNVSQL	0.771	0.5901	-	-	-	-	-	-	-
SIK3 (Q9Y2K2)	Homo sapiens	S329	SGLQSSRSNPSIQAT	0.525	0.7505	-	-	-	-	-	-	-
SIK3 (Q9Y2K2)	Homo sapiens	S162	SALNRTNSDSALHTS	0.89	0.6322	-	-	-	-	-	-	-
SIK3 (Q9Y2K2)	Homo sapiens	S370	SLRLFSLSNPSLSTT	0.898	0.5139	-	-	-	-	-	-	-
SIK3 (Q9Y2K2)	Homo sapiens	S62	LTQYHGGSLPNVSQL	0.771	0.5901	-	-	-	-	-	-	-
SIK2 (Q9H0K1)	Homo sapiens	S329	SGLQSSRSNPSIQAT	0.525	0.7505	-	-	-	-	-	-	-
SIK2 (Q9H0K1)	Homo sapiens	S162	SALNRTNSDSALHTS	0.89	0.6322	-	-	-	-	-	-	-
SIK2 (Q9H0K1)	Homo sapiens	S370	SLRLFSLSNPSLSTT	0.898	0.5139	-	-	-	-	-	-	-
SIK2 (Q9H0K1)	Homo sapiens	S62	LTQYHGGSLPNVSQL	0.771	0.5901	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found