CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

SIK3

Synonyms

KIAA0999 QSK

Protein Name

Serine/threonine-protein kinase SIK3

UniProt ID

Q9Y2K2

Ensembl Gene ID

9606.ENSP00000292055

NCBI Gene ID

23387

Molecular Weight

1,44,851

Protein Length

1,321

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.

Function

N/A

Gene Ontology

GO:0000226; GO:0000287; GO:0004674; GO:0005524; GO:0005737; GO:0006468; GO:0035556; GO:0050321

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Crtc3 (Q91X84)	Mus musculus	S329	SGLQSSRSNPSIQAT	-	0.725	-	-	-	-	-	-	in-vitro
Crtc3 (Q91X84)	Mus musculus	S162	SALNRTNSDSALHTS	-	0.6375	-	-	-	-	-	-	in-vitro
Crtc3 (Q91X84)	Mus musculus	S370	SLRLFSLSNPSLSTT	-	0.4979	-	-	-	-	-	-	in-vitro
Crtc3 (Q91X84)	Mus musculus	S62	LTQYHGGSLPNVSQL	-	0.6183	-	-	-	-	-	-	in-vitro
CRTC2 (Q53ET0)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
CRTC2 (Q53ET0)	Homo sapiens	S348	PSLQSSLSNPNLQAS	0.949	0.7163	-	-	-	-	-	-	-
CRTC2 (Q53ET0)	Homo sapiens	S70	RSSHYGGSLPNVNQI	0.754	0.562	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S329	SGLQSSRSNPSIQAT	0.525	0.7505	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S162	SALNRTNSDSALHTS	0.89	0.6322	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S370	SLRLFSLSNPSLSTT	0.898	0.5139	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S62	LTQYHGGSLPNVSQL	0.771	0.5901	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found