| Gene |
Abi1
|
| Protein Name |
ABI1_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1) |
| Protein Family |
ABI family |
| NCBI Gene ID |
11308
|
| UniProt ID |
Q8CBW3
|
| Enzyme Class |
- |
| Molecular Weight |
52288 |
| Protein Length |
481 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. |
| Gene Ontology |
GO:0001756; GO:0005622; GO:0005634; GO:0005856; GO:0008134; GO:0008154; GO:0014069; GO:0017124; GO:0018108; GO:0030027; GO:0030054; GO:0030296; GO:0030426; GO:0031209; GO:0031252; GO:0032433; GO:0035855; GO:0043005; GO:0044877; GO:0045211; GO:0048813; GO:0072673; GO:0098978; GO:0099527 |
