CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	RPTOR
Protein Name	RPTOR_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
Protein Family	WD repeat RAPTOR family
NCBI Gene ID	57521
UniProt ID	Q8N122
Enzyme Class	-
Molecular Weight	149038
Protein Length	1335
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm. Lysosome. Cytoplasmic granule Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
Function (UniProt annotation)	Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
Gene Ontology	GO:0001030; GO:0001031; GO:0001032; GO:0001156; GO:0001558; GO:0001938; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0007050; GO:0008361; GO:0009267; GO:0010494; GO:0010800; GO:0016032; GO:0016241; GO:0019901; GO:0030291; GO:0030295; GO:0030307; GO:0030425; GO:0030674; GO:0031669; GO:0031929; GO:0031931; GO:0032008; GO:0033138; GO:0038202; GO:0043025; GO:0044877; GO:0045945; GO:0071230; GO:0071233; GO:0071889; GO:0071902; GO:1900034; GO:1900087

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Prkaa1 (Q5EG47)	Mus musculus	S722	PRLRSVSSYGNIRAV	0.794	0.3215	TP	certain	experimental	55 \| 30 \| 72 \| 73 \| 9 \|	18439900	-	-
Prkaa2 (Q8BRK8)	Mus musculus	S722	PRLRSVSSYGNIRAV	0.794	0.3215	TP	certain	experimental	55 \| 30 \| 72 \| 73 \| 9 \|	18439900	-	-
Prkaa1 (Q5EG47)	Mus musculus	S792	DKMRRASSYSSLNSL	0.494	0.3704	TP	certain	experimental	55 \| 9 \|	18439900	-	-
Prkaa2 (Q8BRK8)	Mus musculus	S792	DKMRRASSYSSLNSL	0.494	0.3704	TP	certain	experimental	55 \| 9 \|	18439900	-	-
PRKAA1 (Q13131)	Homo sapiens	S792	DKMRRASSYSSLNSL	0.494	0.3704	-	-	-	-	-	-	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S719	PCTPRLRSVSSYGNI	0.155	0.384	-	-	-	-	-	-	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S721	TPRLRSVSSYGNIRA	0.834	0.346	-	-	-	-	-	-	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S722	PRLRSVSSYGNIRAV	0.794	0.3215	-	-	-	-	-	-	In vitro and in vivo
PRKAA1 (Q13131)	Homo sapiens	S722	PRLRSVSSYGNIRAV	0.794	0.3215	-	-	-	-	-	-	in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04150	mTOR signaling pathway
hsa04910	Insulin signaling pathway

NCI Nature PID Pathways

Pathway ID	Pathway Name
mtor_4pathway	mTOR signaling pathway
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt