CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | Q9BUB5 | Eif4e | SPRY2 | SFPQ | HNRNPA1 | EIF4E | Pla2g4a | PNPLA8 | PLA2G4A | | EIF4E | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| AKT1 | RAC-alpha serine/threonine-protein kinase | P31749 | MAPKAPK2 | SIK2 | PRKD1 | CAMKK2 | |
| EIF4E | Eukaryotic translation initiation factor 4E | P06730 | MKNK2 | MKNK1 | |
| IRS1 | Insulin receptor substrate 1 | P35568 | Sik2 | SIK1 | RPS6KA1 | PIM2 | PIM3 | PIM1 | SIK2 | |
| MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Q99683 | PIM1 | Melk | RPS6KA3 | PRKD1 | MELK | |
| PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | Q14738 | CHEK1 | |
| PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | Q9Y478 | PRKAA1 | |
| PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | P60484 | STK11 | |
| RPS6 | 40S ribosomal protein S6 | P62753 | RPS6KA3 | DAPK1 | RPS6KA1 | PASK | |
| RPTOR | Regulatory-associated protein of mTOR | Q8N122 | Prkaa1 | Prkaa2 | PRKAA1 | RPS6KA1 | |
| TSC2 | Tuberin | P49815 | MAPKAPK2 | PIM2 | RPS6KA1 | BRSK2 | |