CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	SSH1
Protein Name	SSH1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)
Protein Family	Protein-tyrosine phosphatase family
NCBI Gene ID	54434
UniProt ID	Q8WYL5
Enzyme Class	3.1.3.16; 3.1.3.48
Molecular Weight	115511
Protein Length	1049
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Localization	Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
Function (UniProt annotation)	Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Gene Ontology	GO:0000902; GO:0003779; GO:0004721; GO:0004725; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006470; GO:0008064; GO:0008138; GO:0010591; GO:0030027; GO:0030036; GO:0030426; GO:0030496; GO:0031915; GO:0032154; GO:0032268; GO:0050770; GO:0071318; GO:0098976; GO:1901216; GO:1904719; GO:1904754; GO:2000463

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD2 (Q9BZL6)	Homo sapiens	S937	SNLTRSSSSDSIHSV	0.839	0.7036	TP	certain	experimental	73 \| 55 \| 8 \|	19567672	-	-
PRKD2 (Q9BZL6)	Homo sapiens	S978	SPLKRSHSLAKLGSL	0.802	0.4441	TP	certain	experimental	73 \| 55 \| 8 \|	19567672	-	-
PRKD1 (Q15139)	Homo sapiens	S978	SPLKRSHSLAKLGSL	0.802	0.4441	TP	certain	experimental	72 \| 73 \| 55 \| 9 \| 143 \|	19329994	-	-
PRKD1 (Q15139)	Homo sapiens	S402	MGVSRSASTVIAYAM	0.666	0.1671	-	-	-	-	-	-	In vitro
PRKD1 (Q15139)	Homo sapiens	S937	SNLTRSSSSDSIHSV	0.839	0.7036	-	-	-	-	-	-	In vitro and in vivo
CAMK2D (Q13557)	Homo sapiens	S937	SNLTRSSSSDSIHSV	0.839	0.7036	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S978	SPLKRSHSLAKLGSL	0.802	0.4441	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04810	Regulation of actin cytoskeleton

NCI Nature PID Pathways

Pathway ID	Pathway Name
fgf_pathway	FGF signaling pathway