CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Crtc3
Protein Name	CRTC3_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)
Protein Family	TORC family
NCBI Gene ID	70461
UniProt ID	Q91X84
Enzyme Class	-
Molecular Weight	67027
Protein Length	619
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Gene Ontology	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008140; GO:0032793; GO:0042116; GO:0043951; GO:0045944; GO:0050995; GO:0051289; GO:0097009

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
SIK3 (Q9Y2K2)	Homo sapiens	S329	SGLQSSRSNPSIQAT	N/A	0.725	-	-	-	-	-	-	in-vitro
SIK3 (Q9Y2K2)	Homo sapiens	S162	SALNRTNSDSALHTS	N/A	0.6375	-	-	-	-	-	-	in-vitro
SIK3 (Q9Y2K2)	Homo sapiens	S370	SLRLFSLSNPSLSTT	N/A	0.4979	-	-	-	-	-	-	in-vitro
SIK3 (Q9Y2K2)	Homo sapiens	S62	LTQYHGGSLPNVSQL	N/A	0.6183	-	-	-	-	-	-	in-vitro
SIK1 (P57059)	Homo sapiens	S329	SGLQSSRSNPSIQAT	N/A	0.725	-	-	-	-	-	-	in-vitro
SIK1 (P57059)	Homo sapiens	S162	SALNRTNSDSALHTS	N/A	0.6375	-	-	-	-	-	-	in-vitro
SIK1 (P57059)	Homo sapiens	S370	SLRLFSLSNPSLSTT	N/A	0.4979	-	-	-	-	-	-	in-vitro
SIK1 (P57059)	Homo sapiens	S62	LTQYHGGSLPNVSQL	N/A	0.6183	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S329	SGLQSSRSNPSIQAT	N/A	0.725	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S162	SALNRTNSDSALHTS	N/A	0.6375	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S370	SLRLFSLSNPSLSTT	N/A	0.4979	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S62	LTQYHGGSLPNVSQL	N/A	0.6183	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found