CaMKinet | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Parameter	Value
Gene	ARHGEF2
Protein Name	ARHG2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Protein Family	N/A
NCBI Gene ID	9181
UniProt ID	Q92974
Enzyme Class	-
Molecular Weight	111543
Protein Length	986
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm, cytoskeleton
Function (UniProt annotation)	Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity).
Gene Ontology	GO:0000132; GO:0000902; GO:0002102; GO:0005085; GO:0005089; GO:0005737; GO:0005794; GO:0005819; GO:0005829; GO:0005856; GO:0005874; GO:0005923; GO:0005925; GO:0006886; GO:0007015; GO:0007026; GO:0007186; GO:0008017; GO:0008134; GO:0008270; GO:0017048; GO:0030676; GO:0031410; GO:0031982; GO:0032587; GO:0032755; GO:0032760; GO:0032991; GO:0035023; GO:0035556; GO:0042127; GO:0043025; GO:0043065; GO:0043198; GO:0045087; GO:0045666; GO:0045944; GO:0048365; GO:0050731; GO:0050768; GO:0051056; GO:0051092; GO:0055059; GO:0060546; GO:0071225; GO:0071356; GO:0071474; GO:0071802; GO:0098978; GO:0099092; GO:1902042; GO:1902219; GO:2001224

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S172	LGLRRILSQSTDSLN	0.967	0.4507	-	-	-	-	-	-	in-vitro
MARK2 (Q7KZI7)	Homo sapiens	S186	NMRNRTLSVESLIDE	0.871	0.3631	-	-	-	-	-	-	in-vivo
MARK2 (Q7KZI7)	Homo sapiens	S172	LGLRRILSQSTDSLN	0.967	0.4507	-	-	-	-	-	-	in-vivo
MARK2 (Q7KZI7)	Homo sapiens	S143	GSRRGRSSLSLAKSV	0.323	0.3704	-	-	-	-	-	-	in-vivo
MARK3 (P27448)	Homo sapiens	S151	LSLAKSVSTTNIAGH	0.861	0.3529	-	-	-	-	-	-	in-vitro and in-vivo
MARK2 (Q7KZI7)	Homo sapiens	S886	PVDPRRRSLPAGDAL	0.517	0.6755	-	-	-	-	-	-	-
MARK2 (Q7KZI7)	Homo sapiens	S960	SRLSPPHSPRDFTRM	0.822	0.8991	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa05130	Pathogenic Escherichia coli infection

NCI Nature PID Pathways

Pathway ID	Pathway Name
reelinpathway	Reelin signaling pathway