| Gene |
RCHY1
|
| Protein Name |
ZN363_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) |
| Protein Family |
N/A |
| NCBI Gene ID |
25898
|
| UniProt ID |
Q96PM5
|
| Enzyme Class |
2.3.2.27 |
| Molecular Weight |
30110 |
| Protein Length |
261 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. |
| Localization |
Nucleus. Nucleus speckle. Cytoplasm. |
| Function (UniProt annotation) |
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. |
| Gene Ontology |
GO:0000151; GO:0002039; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016567; GO:0016607; GO:0031398; GO:0032436; GO:0042803; GO:0051865; GO:0070987 |
