KEGG pathway - p53 signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
CHEK1	Serine/threonine-protein kinase Chk1	O14757	TLK1 \| CHEK1 \| CDC25A \| ERRFI1 \| FANCD2 \| NEK11 \| TLK1 \| E2F6 \| RASSF1 \| FANCE \| E2F3 \| E2F3 \| MDM4 \| TP73 \| Mdm4 \| TP53 \| RB1 \| MAPT \| NFKB1 \| CDC25B \| CDC25C \| MCM4 \| SYK \| BLM \| \| PPP2R5D \| Bad \| AURKB \| LATS2 \| ING1 \| TLK1 \| CSNK2B \| RELA \| CSNK2B \| CLSPN \| Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i \| H3F3A; H3F3B \| CTR9 \| DDX19A \| BAZ1A \| TRIP12 \| CLK3 \| EPRS \| SETMAR \| Csnk1d \| PRR5 \| GTF3C1 \| Cdkn1c \| INF2 \| TICRR \| TFDP1 \| TP53BP1 \| ZNF638 \| SCAF11 \| SRRM2 \| GOLGA4 \| ADD3 \| KIFC1 \| MATR3 \| RIF1 \| E2f7 \| CWC25 \| RBM14 \| IDI1 \| CAAP1 \| PRRC2C \| PHF2 \| HNRNPM \| CCDC6 \| WIZ \| NUP153 \| E2f8 \| SLTM \| OGT \| SSBP1 \| KPNA2 \| MCM3 \| POP4 \| ADD2 \| RAVER1 \| ADD1 \| ANKRD12 \| ZNF395 \| XRCC6 \| MAD2L1 \| MYCBP2 \| RPL19 \| BUD13 \| TBC1D4 \| DDX24 \| CTTN \| RBM42 \| TRIM28 \| MYBBP1A \| SENP2 \| CAMSAP2 \| PRRC2B \| LMNA \| ZBTB11 \| PHF8 \| RACGAP1 \| DDX19B \| TLK2 \| ARHGEF2 \| PPME1 \| PRPF3 \| PROSER2 \| CDK13 \| RRP12 \| Cdkn1a \| DRG2 \| PLRG1 \| HIVEP1 \| NCBP3 \| CDK1 \| Errfi1 \| POLDIP3 \| LIG1 \| KPNA1 \| OSBPL11 \| UIMC1 \| TNK1 \| EML3 \| CEP170B \| LMO7 \| LAMC1 \| HNRNPA2B1 \| YBX1 \| RBM26 \| YBX3 \| MKI67 \| RALY \| CHD7 \| SEPT7; \| MCM5 \| SPEN \| MED1 \| YBX2 \| ZC3HC1 \| MDC1 \| STK4 \| MAP2K2 \| FEN1 \| EBNA1BP2 \| RANBP2 \| CHTOP \| MAP4 \| HDLBP \| NHS \| FYTTD1 \| RPL13 \| MINK1 \| MAP2K1 \| SIN3A \| MDM4 \| \| BAD \| TP53 \| CDC25A \| \| CSNK1D \| CSNK1D \| \| ERRFI1 \| BRCA2 \| HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J \| \|
CHEK2	Serine/threonine-protein kinase Chk2	O96017	E2F3 \| E2F3 \| MDM4 \| REV3L \| CHEK2 \| MBP \| TP53 \| RB1 \| MAPT \| HIST1H1C \| XRCC1 \| PML \| CDC25A \| CDC25C \| BRCA1 \| VHL \| \| E2F1 \| FOXM1 \| TRIM28 \| ELAVL1 \| LATS2 \| AATF \| TTK \| Cds1 \| SIAH2 \| BAIAP2L1 \| PSME3 \| CDK11B \| BLM \| BDNF \| MBP \| CHEK2 \| CHEK2 \| PML \| FOXM1 \| CDK11A \| CHEK2 \| BRCA2 \| MBP \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
ATM	Serine-protein kinase ATM	Q13315
CDKN1A	Cyclin-dependent kinase inhibitor 1	P38936	PIM2 \| PIM1 \| Stk11 \| DAPK3 \| NUAK1 \| DAPK1 \|
CHEK1	Serine/threonine-protein kinase Chk1	O14757	CHEK1 \| PIM1 \| PIM2 \| RPS6KA1 \|
CHEK2	Serine/threonine-protein kinase Chk2	O96017	CHEK2 \|
MDM2	E3 ubiquitin-protein ligase Mdm2	Q00987	MAPKAPK2 \| PIM1 \| DAPK1 \| DAPK3 \| RPS6KA1 \| PIM2 \|
MDM4	Protein Mdm4	O15151	Prkaa1 \| CHEK1 \| CHEK2 \|
PTEN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	P60484	STK11 \|
RCHY1	RING finger and CHY zinc finger domain-containing protein 1	Q96PM5	CAMK2A \|
TP53	Cellular tumor antigen p53	P04637	DAPK1 \| MAPKAPK2 \| STK11 \| NUAK1 \| MAPKAPK5 \| STK17A \| CHEK1 \| DAPK3 \| CHEK2 \| PRKAA1 \| SIK1 \| MELK \| PRKAA2 \|
TP73	Tumor protein p73	O15350	CHEK1 \| PRKAA1 \|
TSC2	Tuberin	P49815	MAPKAPK2 \| PIM2 \| RPS6KA1 \| BRSK2 \|