| Gene |
CARD11
|
| Protein Name |
CAR11_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) |
| Protein Family |
N/A |
| NCBI Gene ID |
84433
|
| UniProt ID |
Q9BXL7
|
| Enzyme Class |
- |
| Molecular Weight |
133284 |
| Protein Length |
1154 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. |
| Gene Ontology |
GO:0001772; GO:0001819; GO:0002223; GO:0002377; GO:0004385; GO:0005737; GO:0005829; GO:0005886; GO:0007249; GO:0030183; GO:0030890; GO:0031295; GO:0032449; GO:0038095; GO:0038202; GO:0042100; GO:0042102; GO:0042981; GO:0043123; GO:0045061; GO:0045086; GO:0045121; GO:0045577; GO:0045580; GO:0048872; GO:0050700; GO:0050852; GO:0051092; GO:0070062; GO:0070970 |
