CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	SIK2
Protein Name	SIK2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
Protein Family	Protein kinase superfamily
NCBI Gene ID	23235
UniProt ID	Q9H0K1
Enzyme Class	2.7.11.1
Molecular Weight	103915
Protein Length	926
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cytoplasm
Function (UniProt annotation)	Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Gene Ontology	GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0031588; GO:0032007; GO:0035556; GO:0042149; GO:0046626; GO:0046777

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK1 (Q14012)	Homo sapiens	T484	RSGQRRHTLSEVTNQ	0.896	0.6576	TP	certain	experimental	55 \| 73 \| 9 \|	21220102	-	-
CAMK4 (Q16566)	Homo sapiens	T484	RSGQRRHTLSEVTNQ	0.896	0.6576	TP	certain	experimental	55 \| 73 \| 9 \|	21220102	-	-
STK11 (Q15831)	Homo sapiens	T175	KSGELLATWCGSPPY	0.707	0.078	TP	certain	experimental	9 \| 55 \| 72 \| 73 \|	14976552	-	-
SIK2 (Q9H0K1)	Homo sapiens	S90	YQVMETKSMLYLVTE	0.001	0.0341	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S343	RLKSHRSSFPVEQRL	0.658	0.3948	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S358	DGRQRRPSTIAEQTV	0.953	0.6227	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found