CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	LATS2
Protein Name	LATS2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Protein Family	Protein kinase superfamily
NCBI Gene ID	26524
UniProt ID	Q9NRM7
Enzyme Class	2.7.11.1
Molecular Weight	120136
Protein Length	1088
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
Function (UniProt annotation)	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
Gene Ontology	GO:0000082; GO:0000922; GO:0004674; GO:0005524; GO:0005634; GO:0005815; GO:0005829; GO:0006468; GO:0009755; GO:0018105; GO:0035329; GO:0035556; GO:0043065; GO:0045736; GO:0046620; GO:0046872; GO:0051301; GO:0090090

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S408	PVPSRTNSFNSHQPR	0.893	0.9057	-	-	-	-	-	-	In vivo
CHEK2 (O96017)	Homo sapiens	S172	TPVTRRPSFEGTGDS	0.526	0.6269	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S380	ATLARRDSLQKPGLE	0.706	0.7629	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S408	PVPSRTNSFNSHQPR	0.893	0.9057	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S446	HILHPVKSVRVLRPE	0.824	0.6269	-	-	-	-	-	-	In vitro
CHEK1 (O14757)	Homo sapiens	S835	GSHVRQDSMEPSDLW	0.672	0.3494	-	-	-	-	-	-	in-vivo
CHEK1 (O14757)	Homo sapiens	S172	TPVTRRPSFEGTGDS	0.526	0.6269	-	-	-	-	-	-	-
CHEK1 (O14757)	Homo sapiens	S380	ATLARRDSLQKPGLE	0.706	0.7629	-	-	-	-	-	-	-
CHEK1 (O14757)	Homo sapiens	S446	HILHPVKSVRVLRPE	0.824	0.6269	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found