| Gene |
DAPK2
|
| Protein Name |
DAPK2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
23604
|
| UniProt ID |
Q9UIK4
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
42898 |
| Protein Length |
370 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm. Cytoplasmic vesicle, autophagosome lumen. |
| Function (UniProt annotation) |
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).; Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. |
| Gene Ontology |
GO:0004674; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005794; GO:0006468; GO:0006915; GO:0010506; GO:0031410; GO:0034423; GO:0035556; GO:0042802; GO:0042981; GO:0043231; GO:0043276; GO:0046777; GO:0090023; GO:1990266; GO:2000424; GO:2001242 |
