CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

DAPK2

Synonyms

N/A

Protein Name

Death-associated protein kinase 2

UniProt ID

Q9UIK4

Ensembl Gene ID

9606.ENSP00000261891

NCBI Gene ID

23604

Molecular Weight

42,898

Protein Length

370

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1zws)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.

Function

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).; Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.

Gene Ontology

GO:0004674; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005794; GO:0006468; GO:0006915; GO:0010506; GO:0031410; GO:0034423; GO:0035556; GO:0042802; GO:0042981; GO:0043231; GO:0043276; GO:0046777; GO:0090023; GO:1990266; GO:2000424; GO:2001242

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
DAPK2 (Q9UIK4)	Homo sapiens	S318	VRRRWKLSFSIVSLC	0.69	0.0676	TP	certain	-	73 \| 62 \| 214 \| 72 \| 31 \|	11230133	-	-
MYL9 (P24844)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.877	0.5665	-	-	-	-	-	-	-
DAPK1 (P53355)	Homo sapiens	S308	ARKKWKQSVRLISLC	-	0.1048	-	-	-	-	-	-	-
STX1A (Q16623)	Homo sapiens	S188	IIMDSSISKQALSEI	0.028	0.3426	-	-	-	-	-	-	-
CAMKK2 (Q96RR4)	Homo sapiens	S511	RREERSLSAPGNLLT	0.556	0.7916	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa05200	Pathways in cancer
hsa05219	Bladder cancer

No NCI Nature pathways found