| Gene |
HDAC5
|
| Protein Name |
HDAC5_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) |
| Protein Family |
Histone deacetylase family |
| NCBI Gene ID |
10014
|
| UniProt ID |
Q9UQL6
|
| Enzyme Class |
3.5.1.98 |
| Molecular Weight |
121978 |
| Protein Length |
1122 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Localization |
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1. |
| Function (UniProt annotation) |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
| Gene Ontology |
GO:0000118; GO:0000122; GO:0000978; GO:0001085; GO:0003682; GO:0004407; GO:0005080; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006325; GO:0006338; GO:0006342; GO:0006476; GO:0006954; GO:0008134; GO:0010830; GO:0010832; GO:0014823; GO:0016575; GO:0016607; GO:0030182; GO:0030183; GO:0032041; GO:0032869; GO:0033558; GO:0040029; GO:0042113; GO:0042220; GO:0042826; GO:0043393; GO:0045892; GO:0045944; GO:0046872; GO:0051091; GO:0070491; GO:0071222; GO:0090051 |
