CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	PRKAB1
Protein Name	AAKB1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)
Protein Family	5'-AMP-activated protein kinase beta subunit family
NCBI Gene ID	5564
UniProt ID	Q9Y478
Enzyme Class	-
Molecular Weight	30382
Protein Length	270
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Gene Ontology	GO:0004672; GO:0004679; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006468; GO:0006633; GO:0007050; GO:0007165; GO:0010628; GO:0016236; GO:0019901; GO:0031588; GO:0035878; GO:0050790; GO:0051291; GO:0120162

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S108	SKLPLTRSHNNFVAI	0.861	0.2817	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	S174	MVDSQKCSDVSELSS	0.22	0.4409	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	S177	SQKCSDVSELSSSPP	0.214	0.4652	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	S24	HKTPRRDSSGGTKDG	0.763	0.9346	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	T158	NIIQVKKTDFEVFDA	0.163	0.1229	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	T80	APAQARPTVFRWTGG	0.836	0.662	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	T148	IVTSQLGTVNNIIQV	0.405	0.3807	-	-	-	-	-	-	in-vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04910	Insulin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05410	Hypertrophic cardiomyopathy (HCM)

NCI Nature PID Pathways

Pathway ID	Pathway Name
mtor_4pathway	mTOR signaling pathway