KEGG pathway - Hypertrophic cardiomyopathy (HCM)

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Q13131	Slc12a1 \| EEF2K \| ACACB \| ULK1 \| Gabbr2 \| Mylk \| Rb1 \| TNNI3 \| NOS3 \| NOS3 \| CSNK1E \| Tsc2 \| Kcnj11 \| Cry1 \| GFPT1 \| Kcnma1 \| PPP2R5C \| PFKFB3 \| TBC1D1 \| Cdkn1b \| CDKN1B \| VASP \| Med1 \| FOXO3 \| EP300 \| HDAC5 \| Kcnb1 \| CFTR \| CTBP1 \| KPNA2 \| GBF1 \| PFKFB2 \| Ulk1 \| TP53 \| Lipe \| HNF4A \| Tsc2 \| LIPE \| GFPT1 \| KLC1 \| PRKAA1 \| SLC12A1 \| RPTOR \| Mlxipl \| ZNF692 \| KLC2 \| RRN3 \| PPP1R3C \| PRKAB1 \| Gabbr1 \| Mtor \| ATG9A \| Nfe2l2 \| Pde4b \| Foxo3 \| NET1 \| FH \| Tnni3 \| SNX17 \| GAPDH \| JAK1 \| YAP1 \| EPM2A \| Sqstm1 \| Atp6v1a \| MAPT \| GLI1 \| DDIT3 \| PRPS2 \| PPP1R12C \| Med1 \| PRPS1 \| PIAS1 \| USP10 \| MKNK1 \| Braf \| FANCA \| KIF4A \| TP73 \| Pnpla2 \| Gatad2a \| SREBF1 \| TXNIP \| CGN \| POU2F1 \| BRAF \| SYK \| ACSS2 \| Nr2c2 \| SQSTM1 \| Map4 \| RACK1 \| PAQR3 \| EGFR \| ERBB2 \| BECN1 \| Cnbp \| EZH2 \| SIRT2 \| CTTN \| FOXO1 \| CYCS \| CNBP \| NFE2L2 \| MYLK \| \| \| RAF1 \| MAPT \| GYS2 \| ACACA \| ACACA \| GABBR2 \| RB1 \| \| KCNB1 \| NOS3 \| TSC2 \| TSC2 \| CRY1 \| KCNMA1 \| MLXIPL \| GABBR1 \| ACACA \| \| ATP6V1A \| MED1 \| BRAF \| PNPLA2 \| GATAD2A \| NR2C2 \| MAP4 \| TSC2 \| PRKCQ \| MTOR \| CYCS \|
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2	P54646	FOXO3 \| Vasp \| PLD1 \| HAS2 \| SIRT1 \| TP73 \| Tp53 \| IKBKB \| Ppargc1a \| Kcnb1 \| ACACA \| Tbc1d4 \| HDAC5 \| PARP1 \| EEF2K \| DUSP1 \| Parp1 \| GLI1 \| TFAP2A \| Prkaa2 \| PPARGC1A \| PFKFB2 \| ULK1 \| NOS3 \| CTNNB1 \| ACACA \| ACACA \| CRTC2 \| TBC1D1 \| TP53 \| KCNB1 \| VASP \| TBC1D4 \| ACACB \| PARP1 \| FYN \| PPARGC1A \| \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
CACNA1C	Voltage-dependent L-type calcium channel subunit alpha-1C	Q13936	PRKD1 \| CAMK2A \|
CACNB2	Voltage-dependent L-type calcium channel subunit beta-2	Q08289
ITGB1	Integrin beta-1	P05556	CAMK2A \|
ITGB4	Integrin beta-4	P16144	RPS6KA1 \|
MYBPC3	Myosin-binding protein C, cardiac-type	Q14896	PRKD1 \|
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Q13131	Prkaa1 \| PRKAA1 \| CAMK2B \| BRSK2 \| CAMKK1 \| BRSK1 \| CAMKK2 \| PRKD1 \|
PRKAB1	5'-AMP-activated protein kinase subunit beta-1	Q9Y478	PRKAA1 \|
RYR2	Ryanodine receptor 2	Q92736	CAMK2A \| CAMK2D \| CAMK2B \| CAMK2G \|
TNNI3	Troponin I, cardiac muscle	P19429	PRKAA1 \| PRKD1 \| PHKG1 \| PHKG2 \|