| Gene |
Pacsin1
|
| Protein Name |
PACN1_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Protein kinase C and casein kinase substrate in neurons protein 1 (Dynamin proline-rich domain-interacting protein) (Dynamin PRD-interacting protein) (Synaptic, dynamin-associated protein I) (Syndapin-1) (Syndapin-I) (SdpI) |
| Protein Family |
PACSIN family |
| NCBI Gene ID |
29704
|
| UniProt ID |
Q9Z0W5
|
| Enzyme Class |
- |
| Molecular Weight |
50449 |
| Protein Length |
441 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Cell projection. Cell junction, synapse, synaptosome. Cell projection, ruffle membrane |
| Function (UniProt annotation) |
Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. |
| Gene Ontology |
GO:0005543; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0007010; GO:0007015; GO:0008092; GO:0030054; GO:0030659; GO:0032587; GO:0043195; GO:0043679; GO:0045202; GO:0048471; GO:0048488; GO:0048812; GO:0072657; GO:0072659; GO:0097320; GO:0098839; GO:0098978; GO:0099149; GO:1900006 |
