CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

CAMKK2

Synonyms

CAMKKB KIAA0787

Protein Name

Calcium/calmodulin-dependent protein kinase kinase 2

UniProt ID

Q96RR4

Ensembl Gene ID

9606.ENSP00000312741

NCBI Gene ID

10645

Molecular Weight

64,746

Protein Length

588

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 6brc)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Nucleus Cytoplasm Cell projection Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Gene Ontology

GO:0000165; GO:0001934; GO:0004683; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005622; GO:0005634; GO:0005829; GO:0006468; GO:0019722; GO:0034614; GO:0042995; GO:0045859; GO:0045893; GO:0046777; GO:0061762; GO:1903599

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Prkaa1 (P54645)	Rattus norvegicus	T183	SDGEFLRTSCGSPNY	-	0.2951	-	-	-	-	-	-	In vitro
PRKAA1 (Q13131)	Homo sapiens	T183	SDGEFLRTSCGSPNY	0.698	0.2951	-	-	-	-	-	-	In vivo
Pacsin1 (Q9Z0W5)	Rattus norvegicus	T355	DRGQAYATEWSDDES	-	0.7209	-	-	-	-	-	-	in-vivo
CAMKK2 (Q96RR4)	Homo sapiens	T85	GQEVPLDTSGSQARP	0.032	0.7951	-	-	-	-	-	-	in-vitro
AKT1 (P31749)	Homo sapiens	T308	KDGATMKTFCGTPEY	0.71	0.2715	-	-	-	-	-	-	in-vitro

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04920	Adipocytokine signaling pathway

No NCI Nature pathways found