PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Kinase Substrate Both Localization legend

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Sequence Viewer
Gene
PHKG1
Synonyms
PHKG
Protein Name
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
UniProt ID
P00518 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSOCUP00000011717
NCBI Gene ID
100009297
Molecular Weight
44803
Protein Length
387
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2phk)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.19; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.[tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+)[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+)ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Function
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.
Gene Ontology
GO:0005964; GO:0098723; GO:0005524; GO:0005516; GO:0004689; GO:0050321; GO:0005978