CaMKinet | Result

Gene

RPS6KA2

Synonyms

MAPKAPK1C RSK3

Protein Name

Ribosomal protein S6 kinase alpha-2

UniProt ID

Q15349 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000265678

NCBI Gene ID

6196

Molecular Weight

83239

Protein Length

733

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Nucleus,Cytoplasm;

Function

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Gene Ontology

GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005524; GO:0016301; GO:0000287; GO:0004674; GO:0004712; GO:0004711; GO:0035556; GO:0045786; GO:0008285; GO:0043065; GO:0007165