CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Kinase Substrate Both Localization legend

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Sequence Viewer
Gene
CAMK1D
Synonyms
CAMKID
Protein Name
Calcium/calmodulin-dependent protein kinase type 1D
UniProt ID
Q8IU85 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000368122
NCBI Gene ID
57118
Molecular Weight
42914
Protein Length
385
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2jc6)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.17; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
Gene Ontology
GO:0005737; GO:0005634; GO:0005524; GO:0005516; GO:0004683; GO:0006954; GO:0043066; GO:0043065; GO:0032793; GO:0010976; GO:0090023; GO:0050766; GO:0060267; GO:0050773; GO:0071622