STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein][tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+)[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+)

Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Perinuclear region,Endoplasmic reticulum;

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.

GO:0005813; GO:0005737; GO:0150034; GO:0005783; GO:0005634; GO:0048471; GO:0005524; GO:0051117; GO:0060590; GO:0000287; GO:0019901; GO:0004674; GO:0048156; GO:0050321; GO:0031532; GO:0007409; GO:0051301; GO:0036503; GO:0030010; GO:0006887; GO:0000086; GO:0035556; GO:0070059; GO:0090176; GO:0030182; GO:0018105; GO:0006468; GO:0043462; GO:0050770; GO:0061178; GO:0010975; GO:1904152; GO:2000807