CaMKinet | Result

Gene

TTN

Synonyms

Protein Name

Titin

UniProt ID

Q8WZ42 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000343764

NCBI Gene ID

7273

Molecular Weight

3816030

Protein Length

34350

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1tki)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Cytoplasm,Nucleus;

Function

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Gene Ontology

GO:0000794; GO:0005829; GO:0070062; GO:0005576; GO:0031674; GO:0031430; GO:0030017; GO:0005865; GO:0030018; GO:0051015; GO:0042805; GO:0005524; GO:0005509; GO:0005516; GO:0019899; GO:0042802; GO:0051371; GO:0002020; GO:0019901; GO:0043621; GO:0004674; GO:0004713; GO:0008307; GO:0097493; GO:0031433; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0035995; GO:0007076; GO:0006936; GO:0030049; GO:0002576; GO:0010628; GO:0050714; GO:0010737; GO:0050790; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0006941; GO:0071688