CaMKinet | Result

Gene

CAMKK2

Synonyms

CAMKKB KIAA0787

Protein Name

Calcium/calmodulin-dependent protein kinase kinase 2

UniProt ID

Q96RR4 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000312741

NCBI Gene ID

10645

Molecular Weight

64746

Protein Length

588

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 6brc)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Nucleus,Cytoplasm,Cell projection;

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Gene Ontology

GO:0042995; GO:0005829; GO:0005622; GO:0005634; GO:0005524; GO:0005509; GO:0005516; GO:0004683; GO:0004713; GO:0019722; GO:0061762; GO:0034614; GO:0000165; GO:1903599; GO:0001934; GO:0045893; GO:0046777; GO:0006468; GO:0045859